Naiza Khan was trained at the Ruskin School of Art, University of Oxford, and the Wimbledon College of Art, London. Her work has been widely exhibited internationally, including at the Kochi-Muziris Biennale (2016), the Shanghai Biennale (2012), as well as in exhibitions, such as Hanging Fire: Contemporary Art from Pakistan, Asia Society, New York, (2009); Art Decoding Violence, XV Biennale Donna, Ferrara (2012); Desperately Seeking Paradise, Art Dubai (2008); and Manifesta 8, Murcia (2010).
Naiza has curated three exhibitions of Pakistani contemporary art, including The Rising Tide: New Directions in Art from Pakistan, 1990–2010 at the Mohatta Palace Museum, Karachi.
In 2013, Khan had her first major retrospective at an American institution: Karachi Elegies at the Eli and Edythe Broad Art Museum at Michigan State University, East Lansing, MI. The same year, she received the Prince Claus Award presented by the Dutch Prince Claus Fund in recognition of her exceptional work and initiatives in the fields of art and culture.